NORMAL VERSUS PATHOLOGICAL CARDIAC FIBROBLAST-DERIVED EXTRACELLULAR MATRIX DIFFERENTIALLY MODULATES CARDIOSPHERE-DERIVED CELL PARACRINE PROPERTIES AND COMMITMENT

Human resident cardiac progenitor cells (CPCs) isolated as cardiosphere-derived cells (CDCs) are Kits under clinical evaluation as a therapeutic product for cardiac regenerative medicine.Unfortunately, limited engraftment and differentiation potential of transplanted cells significantly hamper therapeutic success.Moreover, maladaptive remodelling o

The cellular source for tubular regeneration following kidney injury is a matter of dispute, with reports suggesting a stem or progenitor cells as the regeneration here source while linage tracing studies in mice seemingly favor the classical theory, where regeneration is performed by randomly surviving cells.We, and others have previously describe

The system of scientific innovation can be characterized as a complex, multi-layered network of actors, their products and knowledge elements.Despite the progress that has been made, a more comprehensive understanding of the interactions and dynamics of this multi-layered network remains a significant challenge.This paper constructs a multilayer lo